Drug-Induced Nutrient Depletions


Drug Category

Nutrients Depleted

Repletion Suggestions

5-ASA

Sulfasalazine, Colaza®1, Mesalamine

Folic Acid

Folic Acid 800™ or

Folate 5 Plus™

ANEMIA

Aranesp®*, Epogen®, Procrit®*, Neulasta®*

None Reported

 

ANTACIDS

(H-2 Bockers, Proton Pump Inhibitors)

Nexium®*, Prevacid®*, Protonix®*, Maalox®, Mylanta®, Tagamet®, TUMS®, Pepcid®, Zantac®

Calcium (possible) Vitamin B12 (possible) Phosphorus

Vitamin D Folic Acid Iron

Zinc

Vitamin B1

Ca-Zyme™

B12-2000™ Lozenges Bio-D-Mulsion Forte™ Bio-Multi Plus™ or

ProMulti-Plus™ Super Phosphozyme™

ANTIBIOTICS

Amoxicillin*, Ampicillin, Pennicillin, Tetracycline, Cephalosporin, Ciprofloxacin

Bifidobacteria species Lactobacillus species Biotin

Potassium

Vitamin B1

Vitamin B2

Vitamin B3

Vitamin B6

Vitamin B12

Vitamin C Vitamin E Vitamin K Inositol Magnesium Zinc

BioDoph-7 Plus™ BioDophilus Caps™ or

Lactozyme™ Bio-Multi Plus™ or

ProMulti-Plus™ Inositol

Mg-Zyme™

ANTICOAGULANTS

Warfarin*

None Reported.

 

ANTIDEPRESSANTS (SSRI’s)

Lexapro®, Zoloft®*, Prozac®, Zoloft®, Paxil®

Folic Acid

Vitamin B6

Vitamin B12

Vitamin D

EFAs (increased need) Sodium

Optimal EFAs® Caps B12-2000™ Lozenges Bio-D-Mulsion Forte™

ANTI-DIABETICS

Actos®*, Metformin*, Glucotrol®, Avandia®

CoQ10

Folic Acid

Vitamin B12

CoQ-Zyme 30™

B12-2000™ Lozenges

ANTIHISTAMINES

Singulair®*, Zyrtec®*

EFAS (increased need)

Optimal EFAs® Caps

 

Drug Category

Nutrients Depleted

Repletion Suggestions

ANTIRETROVIRALS

Epivir®, Ziagen®

Zinc Copper Vitamin B12

Carnitine

B12-2000™ Lozenges

Bio-Multi Plus™ L-Carnitine HCl

ANTIHYPERTENSIVES

(ACE Inhibitors, Beta-Blockers)

Toprol-XL®*, Norvasc®*, Lisinopril®*, Furosemide*, Chlorthalidone, Digoxin, Clonidine, Propranolol

CoQ10

Phosphorous Potassium Sodium

Zinc Calcium Magnesium Vitamin B1

CoQ-Zyme 30™ Bio-Multi Plus™

ProMulti-Plus™ Mg-Zyme™

Super Phosphozyme™

ANTI-INFLAMMATORIES

Aspirin, Acetaminophen, Ibuprofen, Naproxen

Folic Acid Iron Potassium Sodium Vitamin C Glutathione

Folic Acid 800™ or

Folate 5 Plus™ Bio-Multi Plus™ or ProMulti-Plus™

GSH-Plus™ Bio-C Plus™

BRONCHODILATORS

Advair Diskus*, Singulair*, Albuterol*

Potassium

K-Zyme™

CHOLESTEROL-LOWERING

(STATINS)

Lipitor®*, Zocor®*, Pravachol®, Cholestyramine, Colesevelam, Fenofibrate

COq10

Beta-Carotene

Calcium Folic Acid Iron Magnesium Phosphorus Vitamin A Vitamin B12

Vitamin D Vitamin E Vitamin K

CoQ-Zyme 30™ Bio-Multi Plus™ or

ProMulti-Plus™ Ca-Zyme™

B12-2000™ Lozenges

Folic Acid 800™ or

Folate 5 Plus™ Super Phosphozyme™

CORTICOSTEROIDS

Prednsone, Hydrocortisone, Prednisole, Betamethasone

Calcium Folic Acid Magnesium Potassium Selenium Vitamin A Vitamin B6

Vitamin C Vitamin D Vitamin K Zinc

Osteo-B II® or

Osteo-B Plus® Folic Acid 800™ or

Folate 5 Plus™ Bio-Multi Plus™ or ProMulti-Plus™

Bio-D Mulsion Forte™ Bio-C Plus™

Mg-Zyme™

 

Drug Category

Nutrients Depleted

Repletion Suggestions

DIURETICS

Furosemide, Hydrochlorothiazide, Triamterene

Calcium Magnesium Potassium Sodium Vitamin B1

Vitamin B6

Vitamin C Zinc CoQ10

Folic Acid

CoQ-Zyme 30™ Mg-Zyme™

Bio-Multi Plus™ or ProMulti-Plus™ Folic Acid 800™ or Folate 5 Plus™

Bio-C Plus™

GOUT

Colchicine

Vitamin A Vitamin D Vitamin B12

Folic Acid Iron Potassium

Bio-Multi Plus™ ProMulti-Plus™

Folic Acid 800™ Folate 5 Plus™

Bio-D-Mulsion Forte™ Ca-Zyme™

HORMONE REPLACEMENT THERAPY

Estrace®, Premarin®, Prempro®, Alora®

Vitamin B6

Magnesium

Vitamin B1

Vitamin B2

Biotin

Vitamin B12

Pantothenic Acid

Vitamin C

B12-2000™ Lozenges

Bio-Multi Plus™ or

ProMulti-Plus™ Mg-Zyme™

Bio-C Plus™

LAXATIVES

Vitamin A Vitamin D Vitamin E Calcium Sodium Potassium

Bio-Multi Plus™ ProMulti-Plus™

Ca-Zyme™

ORAL CONTRACEPTIVES

Ortho Cyclen®, Ortho Novum®, Ortho TriCyclen®, Triphasil®, Seasonale®, Yasmin®, Ethinyl Estradiol Plus Norgestrel

Beta Carotene

Vitamin B1

Vitamin B2

Vitamin B3

Vitamin B6

Vitamin B12

Folic Acid Biotin Pantothenic Acid

Vitamin C Magnesium Zinc Tryptophan Tyrosine

B12-2000™ Lozenges

Equi-Fem™ or

PMT™ or

Bio-Multi Plus™ Mg-Zyme

Bio-B Complex™ Amino Sport™

Bio-C Plus™

PSYCHOTHERAPEUTICS

Seroquel®*, Risperdal®*, Zyprexa®*, Haldol, Ami- triptyline

Vitamin B2

CoQ10

Bio-B Complex™ CoQ-Zyme 30™

 

Drug Category

Nutrients Depleted

Repletion Suggestions

RHEUMATOID ARTHRITIS

Enbrel®*, Remicade®*, Methotrexate

Folic Acid

Folic Acid 800™ or

Folate 5 Plus™

SLEEP AIDS

Ambien®*, Lunesta®, Restoil®, Sonata®

None Reported.

F   However, since many sleep aids/sedatives act on the GABA-A receptor com- plex, it may be deduced that they “may” act similar to anti- covulsants which also act on the GABA-A receptor, and whose depletions included: Biotin

Calcium

Folic Acid

Vitamin B12 Vitamin B1

Vitamin D Vitamin K

B-12-2000™ Lozenges

Bio-Multi Plus™ or

ProMulti-Plus™ Ca-Zyme™

THYROID

Synthroid®*, Levothyroxine Sodium*

Iron

Fe-Zyme™

* Indicates a “Top 20” Drug, either by volume of sales or by quantity of prescriptions dispersed. (source: IMS Health© 2006, Pharmacy Times©2007)

This list is meant for informational purposes only. Individuals should not rely solely on this chart for information on drug-nutrient depletions, but rather use it as a starting point or quick reference. Branded drug names are desig- nated as examples for sake of familiarity.  The listing of registered or branded products is not to be construed as singling out the actions of that particular drug, but is meant to be a generalized representative of the drugs within the category. Inclusion on the list is not indicative of endorsement, nor should it be viewed as inclusive. Variations in drug-nutrient depletions may exist between drugs within the same category. Additionally, many drug companies

do not perform mechanistic studies to determine what effect, if any, their medication have on nutrient status. There- fore, listings should act as a generalized guideline, and should not take the place of appropriate and specific advice from a licensed healthcare provider.

Resources

Pelton, Lavalle, Hawkins, Krinsky. Drug-Induced Nutrient Depletion Handbook. Lexi-Comp; 2nd Ed.,2001. Pelton R. Lavalle. The Nutritional Cost of Prescription Drugs., Morton Publishing Co., 2nd Ed., 2004.

Vaglini F, Fox B, The Side Effects Bible:The Dietary Solution to Unwanted Side Effects of Common Medications. Broadway, 2005.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s